menu
Your Cart

ITN1888

ITN1888
  • Catalog: ITN1888
  • Gene/Protein: TRIO
  • Product Description: Immunotag™ TRIO Polyclonal Antibody
385.0000
Price in reward points: 385

Available Options

Immunotag™ TRIO Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein TRIO
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p
Recommended Dilution IHC-p 1:50-300
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity TRIO Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name TRIO
Accession No. O75962 Q0KL02
Description trio Rho guanine nucleotide exchange factor(TRIO) Homo sapiens This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Protein Expression Brain,Epithelium,Fibroblast,Kidney,Lymph,PBMC,T-cell,
Subcellular Localization cytosol,
Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers.,function:Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth.,PTM:Phosphorylated on serine residue(s).,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 DH (DBL-homology) domains.,similarity:Contains 2 PH domains.,similarity:Contains 2 SH3 domains.,similarity:Contains 4 spectrin repeats.,subunit:Interacts to form a complex with leukocyte antigen related protein.,tissue specificity:Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish

Write a review

Note: HTML is not translated!
Bad Good
Captcha

CONNECT WITH US