ITN2008
ITN2008
- Catalog: ITN2008
- Gene/Protein: GPX1
- Product Description: Immunotag™ GPX1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GPX1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | GPX1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | GPX1 |
| Accession No. | P07203 P11352 P04041 |
| Description | glutathione peroxidase 1(GPX1) Homo sapiens The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA cod |
| Cell Pathway/ Category | Glutathione metabolism,Arachidonic acid metabolism,Amyotrophic lateral sclerosis (ALS),Huntington's disease, |
| Protein Expression | Kidney,Placenta,Pooled, |
| Subcellular Localization | cytoplasm,mitochondrion,mitochondrial matrix,cytosol,extracellular exosome,Lewy body, |
| Protein Function | catalytic activity:2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.,function:Protects the hemoglobin in erythrocytes from oxidative breakdown.,online information:Glutathione peroxidase entry,similarity:Belongs to the glutathione peroxidase family.,subunit:Homotetramer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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