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ITN2098

ITN2098
  • Gene/Protein: LTBP1
  • Product Description: Immunotag™ LTBP1 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ LTBP1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein LTBP1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity LTBP1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name LTBP1
Accession No. Q14766 Q8CG19 Q00918
Description latent transforming growth factor beta binding protein 1(LTBP1) Homo sapiens The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category TGF-beta,
Protein Expression Blood,Brain,Fibroblast,Platelet,
Subcellular Localization microfibril,extracellular region,proteinaceous extracellular matrix,extracellular matrix,protein complex,
Protein Function domain:Associates covalently with small latent TGF-beta complex via domain TB 3.,function:May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).,PTM:Contains hydroxylated asparagine residues.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The N-terminus is blocked (isoform Short).,similarity:Belongs to the LTBP family.,similarity:Contains 18 EGF-like domains.,similarity:Contains 4 TB (TGF-beta binding) domains.,subunit:The large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1. Binds to FBN1 and FBN2. Interacts with ADAMTSL2.,tissue specificity:The long isoform is found in fibroblasts.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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