ITN2184
ITN2184
- Catalog: ITN2184
- Gene/Protein: DDC AADC
- Product Description: Immunotag™ DDC Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DDC |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | DDC Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | DDC AADC |
| Accession No. | P20711 O88533 P14173 |
| Description | dopa decarboxylase(DDC) Homo sapiens The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011], |
| Cell Pathway/ Category | Histidine metabolism,Tyrosine metabolism,Phenylalanine metabolism,Tryptophan metabolism, |
| Protein Expression | Lung,Pheochromocytoma,Placenta, |
| Subcellular Localization | cytosol,synaptic vesicle,axon,neuronal cell body,extracellular exosome, |
| Protein Function | catalytic activity:3,4-dihydroxy-L-phenylalanine = dopamine + CO(2).,catalytic activity:5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).,cofactor:Pyridoxal phosphate.,disease:Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.,function:Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.,online information:Aromatic L-amino-acid decarboxylase entry,pathway:Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.,similarity:Belongs to the group II decarboxylase family.,subunit:Homodimer., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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