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ITN2225

  • Gene/Protein: IL1RAPL1 OPHN4
  • Product Description: Immunotag™ IRPL1 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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ITN2225

Immunotag™ IRPL1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein IRPL1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein, at AA range: 340-420
Specificity IRPL1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name IL1RAPL1 OPHN4
Accession No. Q9NZN1 P59823 P59824
Description interleukin 1 receptor accessory protein like 1(IL1RAPL1) Homo sapiens The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities. [provided by RefSeq, Jul 2008],
Protein Expression Brain,Fetal brain,Testis,
Subcellular Localization cytoplasm,plasma membrane,cell surface,integral component of membrane,axon,dendrite,postsynaptic membrane,
Protein Function A number of isoforms are produced,disease:Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected at low levels in heart, skeletal muscle, ovary, skin, and in amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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