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ITN2256

ITN2256
  • Gene/Protein: RSPO3 PWTSR THSD2
  • Product Description: Immunotag™ RSPO3 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ RSPO3 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein RSPO3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity RSPO3 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name RSPO3 PWTSR THSD2
Accession No. Q9BXY4 Q2TJ95
Description R-spondin 3(RSPO3) Homo sapiens This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development. [provided by RefSeq, Jul 2013],
Protein Expression Embryo,Fetal brain,Placenta,
Subcellular Localization extracellular region,
Protein Function domain:The FU repeats are required for activation and stabilization of beta-catenin.,function:Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.,miscellaneous:Upon injection into mice, it induces rapid onset of crypt cell proliferation involving beta-catenin stabilization. It also displays efficacy in a model of chemotherapy-induced intestinal mucositis.,similarity:Belongs to the R-spondin family.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 2 FU (furin-like) repeats.,subunit:Interacts with the extracelular domain of FZD8 and LRP6. It however does not form a ternary complex with FZD8 and LRP6. Interacts with WNT1. Binds heparin.,tissue specificity:Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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