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ITN2349

ITN2349
  • Gene/Protein: FCRL2 FCRH2 IFGP4 IRTA4 SPAP1 UNQ9236/PRO31998
  • Product Description: Immunotag™ FCRL2 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ FCRL2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein FCRL2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 130-210
Specificity FCRL2 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name FCRL2 FCRH2 IFGP4 IRTA4 SPAP1 UNQ9236/PRO31998
Accession No. Q96LA5
Description Fc receptor like 2(FCRL2) Homo sapiens This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009],
Protein Expression Lymph node,Thymus,Tonsil,
Subcellular Localization plasma membrane,integral component of membrane,
Protein Function domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.,function:May have an regulatory role in normal and neoplastic B cell development.,PTM:Isoform 2 is N- and O-glycosylated, and phosphorylated.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:The tyrosine-phosphorylated isoform 2 interacts with PTPN6.,tissue specificity:Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B cells (at protein level).,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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