ITN2349
ITN2349
- Catalog: ITN2349
- Gene/Protein: FCRL2 FCRH2 IFGP4 IRTA4 SPAP1 UNQ9236/PRO31998
- Product Description: Immunotag™ FCRL2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | FCRL2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 130-210 |
| Specificity | FCRL2 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | FCRL2 FCRH2 IFGP4 IRTA4 SPAP1 UNQ9236/PRO31998 |
| Accession No. | Q96LA5 |
| Description | Fc receptor like 2(FCRL2) Homo sapiens This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Apr 2009], |
| Protein Expression | Lymph node,Thymus,Tonsil, |
| Subcellular Localization | plasma membrane,integral component of membrane, |
| Protein Function | domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif bind the SH2 domain of PTPN6.,function:May have an regulatory role in normal and neoplastic B cell development.,PTM:Isoform 2 is N- and O-glycosylated, and phosphorylated.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:The tyrosine-phosphorylated isoform 2 interacts with PTPN6.,tissue specificity:Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B cells (at protein level)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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