menu
Your Cart

ITN2350

ITN2350
  • Gene/Protein: PTP4A3 PRL3
  • Product Description: Immunotag™ TP4A3 Polyclonal Antibody
280.0000
Price in reward points: 294

Available Options

Immunotag™ TP4A3 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein TP4A3
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein . at AA range: 40-120
Specificity TP4A3 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name PTP4A3 PRL3
Accession No. O75365 Q9D658
Description protein tyrosine phosphatase type IVA, member 3(PTP4A3) Homo sapiens This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Protein Expression Eye,Lung fibroblast,Skeletal muscle,
Subcellular Localization nucleus,cytoplasm,early endosome,plasma membrane,
Protein Function Additional isoforms seem to exist,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Significantly overexpressed in liver metastasis of colorectal cancer.,enzyme regulation:Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.,function:Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.,PTM:Farnesylated. Farnesylation is required for membrane targeting.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Interacts with tubulin.,tissue specificity:Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
English_US
Danish
Dutch
English_UK
French
German
Spanish
Norwegian
Portuguese
Finnish
Swedish
Polish

Write a review

Note: HTML is not translated!
Bad Good
Captcha

CONNECT WITH US