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ITN2363

ITN2363
  • Gene/Protein: POSTN OSF2
  • Product Description: Immunotag™ POSTN Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ POSTN Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein POSTN
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity POSTN Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name POSTN OSF2
Accession No. Q15063 Q62009
Description periostin(POSTN) Homo sapiens This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015],
Protein Expression Liver,Osteosarcoma,Periodontal ligament,Placenta,Plasma,
Subcellular Localization proteinaceous extracellular matrix,extracellular space,cytoplasm,trans-Golgi network,extracellular matrix,neuromuscular junction,
Protein Function function:Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.,PTM:Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.,similarity:Contains 1 EMI domain.,similarity:Contains 4 FAS1 domains.,tissue specificity:Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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