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ITN2364

ITN2364
  • Catalog: ITN2364
  • Gene/Protein: CNDP1 CN1 CPGL2 UNQ1915/PRO4380
  • Product Description: Immunotag™ CNDP1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CNDP1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CNDP1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein, at AA range: 330-410
Specificity CNDP1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CNDP1 CN1 CPGL2 UNQ1915/PRO4380
Accession No. Q96KN2 Q8BUG2 Q66HG3
Description carnosine dipeptidase 1(CNDP1) Homo sapiens This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category Histidine metabolism,beta-Alanine metabolism,
Protein Expression Brain,Plasma,Skin,
Subcellular Localization extracellular region,cytosol,
Protein Function catalytic activity:Preferential hydrolysis of the beta-Ala-|-His dipeptide (carnosine), and also anserine, Xaa-|-His dipeptides and other dipeptides including homocarnosine.,cofactor:Binds 2 zinc ions per subunit.,disease:Deficiency of CNDP1 may be the cause of homocarnosinosis.,disease:Diabetic patients with the CNDP1 Mannheim allele are less susceptible for nephropathy.,enzyme regulation:Inhibited by the metal chelator 1,10-o-phenantrolin. The inhibitory concentration 50% (IC(50)) is 5 uM.,polymorphism:The number of trinucleotide (CTG) repeat varies among different alleles leading to insertion of Leu residues in the signal peptide. The allele with 5 leucines (as shown in the reference entry) is known as the Mannheim allele.,similarity:Belongs to the peptidase M20A family.,subunit:Homodimer.,tissue specificity:Expressed in adult nervous central system.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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