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ITN2369

  • Gene/Protein: PRLR
  • Product Description: Immunotag™ PRLR Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

    Available Options

ITN2369

Immunotag™ PRLR Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PRLR
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Rat,Mouse
Host Species Rabbit
Immunogen Synthesized peptide derived from human protein, at AA range: 80-160
Specificity PRLR Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name PRLR
Accession No. P16471 Q08501 P05710
Description prolactin receptor(PRLR) Homo sapiens This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011],
Cell Pathway/ Category Cytokine-cytokine receptor interaction,Neuroactive ligand-receptor interaction,Jak_STAT,
Protein Expression Breast tumor,Mammary carcinoma,Placenta,
Subcellular Localization extracellular region,plasma membrane,cell surface,integral component of membrane,endosome lumen,
Protein Function domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoforms 4 and 6 are unable to transduce prolactin signaling.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subcellular location:Isoform 7.,subunit:Interacts with SMARCA1. Interacts with GH1.,tissue specificity:Expressed in breast, placenta, kidney, liver and pancreas.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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