ITN2371
ITN2371
- Catalog: ITN2371
- Gene/Protein: CRNN C1orf10 DRC1 PDRC1 SEP53
- Product Description: Immunotag™ CRNN Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CRNN |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 380-460 |
| Specificity | CRNN Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | CRNN C1orf10 DRC1 PDRC1 SEP53 |
| Accession No. | Q9UBG3 |
| Description | cornulin(CRNN) Homo sapiens This gene encodes a member of the "fused gene" family of proteins, which contain N-terminus EF-hand domains and multiple tandem peptide repeats. The encoded protein contains two EF-hand Ca2+ binding domains in its N-terminus and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. This gene, also known as squamous epithelial heat shock protein 53, may play a role in the mucosal/epithelial immune response and epidermal differentiation. [provided by RefSeq, Jan 2009], |
| Protein Expression | Fetal oesophagus,Oesophagus,Skeletal muscle, |
| Subcellular Localization | cytoplasm,membrane,extracellular exosome, |
| Protein Function | cofactor:Binds calcium.,domain:The EF-hand is necessary for the colony survival activity to protect cells from death induced by exposure to DCA.,function:Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest.,induction:Up-regulated after heat shock, ponasterone A and deoxycholic acid.,miscellaneous:Binds calcium with an affinity similar to that of the S100 proteins.,similarity:Belongs to the S100-fused protein family.,similarity:Contains 1 EF-hand domain.,subcellular location:Does not colocalize with TGM1.,subunit:Homodimer.,tissue specificity:Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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