ITN2409
ITN2409
- Catalog: ITN2409
- Gene/Protein: PLEKHA1 TAPP1
- Product Description: Immunotag™ PKHA1 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | PKHA1 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 170-250 |
| Specificity | PKHA1 Polyclonal Antibody detects endogenous levels of protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Gene Name | PLEKHA1 TAPP1 |
| Accession No. | Q9HB21 Q8BUL6 |
| Description | pleckstrin homology domain containing A1(PLEKHA1) Homo sapiens This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010], |
| Protein Expression | Brain,Colon,Placenta,Testis, |
| Subcellular Localization | nucleoplasm,cytoplasm,plasma membrane,ruffle membrane,extracellular exosome, |
| Protein Function | domain:Binds to membranes enriched in PtdIns3,4P2 via the C-terminal PH domain.,function:Binds specifically to phosphatidylinositol-3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.,subunit:Binds MPDZ and PTPN13.,tissue specificity:Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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