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ITN2848

ITN2848
  • Catalog: ITN2848
  • Gene/Protein: CAPN1 CANPL1 PIG30
  • Product Description: Immunotag™ CAN1 Polyclonal Antibody
334.0000
Price in reward points: 334

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Immunotag™ CAN1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CAN1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution WB 1:500-2000 ELISA 1:5000-20000
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from part region of human protein
Specificity CAN1 Polyclonal Antibody detects endogenous levels of protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene Name CAPN1 CANPL1 PIG30
Accession No. P07384 O35350 P97571
Description calpain 1(CAPN1) Homo sapiens The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],
Cell Pathway/ Category Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Alzheimer's disease,
Protein Expression Kidney,Pancreas,Placenta,
Subcellular Localization intracellular,cytoplasm,mitochondrion,lysosome,cytosol,plasma membrane,focal adhesion,membrane,extracellular exosome,
Protein Function catalytic activity:Broad endopeptidase specificity.,cofactor:Binds 3 calcium ions.,enzyme regulation:Activated by micromolar concentrations of calcium and inhibited by calpastatin.,function:Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.,online information:Calpain,similarity:Belongs to the peptidase C2 family.,similarity:Contains 1 calpain catalytic domain.,similarity:Contains 4 EF-hand domains.,subcellular location:Translocates to the plasma membrane upon Ca(2+) binding.,subunit:Forms a heterodimer with a small (regulatory) subunit (CAPNS1).,tissue specificity:Ubiquitous.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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