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ITP0070

ITP0070
ITP0070
ITP0070
  • Catalog: ITP0070
  • Gene/Protein: CFL1
  • Product Description: Immunotag™ Cofilin (phospho Ser3) Polyclonal Antibody
490.0000
Price in reward points: 490

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Immunotag™ Cofilin (phospho Ser3) Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CofIL-in (Ser3)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized phospho-peptide around the phosphorylation site of human Cofilin (phospho Ser3)
Specificity Phospho-Cofilin (S3) Polyclonal Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CFL1
Accession No. P23528 P18760 P45592
Alternate Names CFL1; CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform
Description cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004],
Cell Pathway/ Category Axon guidance,Fc gamma R-mediated phagocytosis,Regulates Actin and Cytoskeleton,
Protein Expression B-cell lymphoma,Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Lung,Ovary,Placenta,Platelet
Subcellular Localization extracellular space,nucleus,cytoplasm,focal adhesion,actin cytoskeleton,membrane,nuclear matrix,extracellular matrix,lamellipodium membrane,vesicle,ruffle membrane,extracellular exosome,
Protein Function function:Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.,online information:Cofilin entry,PTM:Phosphorylated on Ser-3 in resting cells.,similarity:Belongs to the actin-binding proteins ADF family.,similarity:Contains 1 ADF-H domain.,subcellular location:Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.,tissue specificity:Widely distributed in various tissues.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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