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ITP0073

ITP0073
  • Gene/Protein: PPP1R14A
  • Product Description: Immunotag™ CPI-17 (phospho Thr38) Polyclonal Antibody
357.0000
Price in reward points: 357

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Immunotag™ CPI-17 (phospho Thr38) Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CPI-17 (Thr38)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized phospho-peptide around the phosphorylation site of human CPI-17 (phospho Thr38)
Specificity Phospho-CPI-17 (T38) Polyclonal Antibody detects endogenous levels of CPI-17 protein only when phosphorylated at T38.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PPP1R14A
Accession No. Q96A00 Q91VC7 Q99MC0
Alternate Names PPP1R14A; CPI17; PPP1INL; Protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC-potentiated inhibitory protein of PP1; Protein kinase C-potentiated inhibitor protein of 17 kDa; CPI-17
Description protein phosphatase 1 regulatory inhibitor subunit 14A(PPP1R14A) Homo sapiens The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011],
Cell Pathway/ Category Vascular smooth muscle contraction,
Protein Expression Aorta,Pancreas,Platelet,Smooth muscle,
Subcellular Localization cytoplasm,cytosol,
Protein Function function:Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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