ITP0673
ITP0673
- Catalog: ITP0673
- Gene/Protein: PTGES3
- Product Description: Immunotag™ p23 (phospho Ser113) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | p23 (Ser113) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human p23 (phospho Ser113) |
| Specificity | Phospho-p23 (S113) Polyclonal Antibody detects endogenous levels of p23 protein only when phosphorylated at S113. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PTGES3 |
| Accession No. | Q15185 Q9R0Q7 P83868 |
| Alternate Names | PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23 |
| Description | prostaglandin E synthase 3(PTGES3) Homo sapiens This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016], |
| Protein Expression | Embryonic kidney,Epithelium,Liver,Lung,Pituitary,Platelet,T-cell,Testis,Uri |
| Subcellular Localization | chromosome, telomeric region,nucleus,nucleoplasm,telomerase holoenzyme complex,cytoplasm,cytosol,extracellular exosome, |
| Protein Function | catalytic activity:(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.,function:Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the p23/wos2 family.,similarity:Contains 1 CS domain.,subunit:Binds to telomerase and to the progesterone receptor., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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