ITP0950
ITP0950
- Catalog: ITP0950
- Gene/Protein: PPP1R1B
- Product Description: Immunotag™ DARPP-32 (phospho Thr34) Polyclonal Antibody
490.0000
Price in reward points: 490
| Antibody Specification | |
| Datasheet | 
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| Target Protein | DARPP-32 (Thr34) |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human DARPP-32 (phospho Thr34) |
| Specificity | Phospho-DARPP-32 (T34) Polyclonal Antibody detects endogenous levels of DARPP-32 protein only when phosphorylated at T34. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | PPP1R1B |
| Accession No. | Q9UD71 Q60829 Q6J4I0 |
| Alternate Names | PPP1R1B; DARPP32; Protein phosphatase 1 regulatory subunit 1B; DARPP-32; Dopamine- and cAMP-regulated neuronal phosphoprotein |
| Description | protein phosphatase 1 regulatory inhibitor subunit 1B(PPP1R1B) Homo sapiens This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011], |
| Protein Expression | Adipose tissue,Brain,Cerebellum,Colon,Ovary, |
| Subcellular Localization | nucleus,cytoplasm,cytosol,neuronal cell body, |
| Protein Function | function:Inhibitor of protein-phosphatase 1.,PTM:Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.,PTM:Phosphorylation of Thr-34 is required for activity.,similarity:Belongs to the protein phosphatase inhibitor 1 family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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