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ITP1098

ITP1098
ITP1098
ITP1098
  • Catalog: ITP1098
  • Gene/Protein: ITPR1
  • Product Description: Immunotag™ IP3R-I (phospho Ser1764) Polyclonal Antibody
490.0000
Price in reward points: 490

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Immunotag™ IP3R-I (phospho Ser1764) Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein IP3R-I (Ser1764)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized phospho-peptide around the phosphorylation site of human IP3R-I (phospho Ser1764)
Specificity Phospho-IP3R-I (S1764) Polyclonal Antibody detects endogenous levels of IP3R-I protein only when phosphorylated at S1764.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name ITPR1
Accession No. Q14643 P11881 P29994
Alternate Names ITPR1; INSP3R1; Inositol 1; 4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Description inositol 1,4,5-trisphosphate receptor type 1(ITPR1) Homo sapiens This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],
Cell Pathway/ Category Calcium,Phosphatidylinositol signaling system,Oocyte meiosis,Vascular smooth muscle contraction,Gap junction,Long-term potentiation,Long-term depression,GnRH,Alzheimer's disease,Huntington's disease,
Protein Expression Brain,Epithelium,Liver,Myeloid,T-cell,Uterus,
Subcellular Localization nuclear inner membrane,nucleolus,endoplasmic reticulum,endoplasmic reticulum membrane,plasma membrane,calcineurin complex,postsynaptic density,membrane,integral component of membrane,sarcoplasmic reticulum,platelet
Protein Function There is a combination of three alternatively spliced domains at site SI, SIII and site SII (A and C). Experimental confirmation may be lacking for some isoforms,disease:Defects in ITPR1 are the cause of spinocerebellar ataxia type 15 (SCA15) (SCA15) [MIM:606658]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA15 is an autosomal dominant cerebellar ataxia (ADCA). It is very slow progressing form with a wide range of onset, ranging from childhood to adult. Most patients remain ambulatory.,domain:The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.,function:Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.,miscellaneous:Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.,PTM:Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the InsP3 receptor family.,similarity:Contains 5 MIR domains.,subunit:Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 (By similarity). Interacts with MRVI1.,tissue specificity:Widely expressed.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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