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ITP1165

ITP1165
  • Catalog: ITP1165
  • Gene/Protein: NTRK1
  • Product Description: Immunotag™ Trk A (phospho Tyr496) Polyclonal Antibody
490.0000
Price in reward points: 490

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Immunotag™ Trk A (phospho Tyr496) Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Trk A (Tyr496)
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IF,ELISA
Recommended Dilution Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized phospho-peptide around the phosphorylation site of human Trk A (phospho Tyr496)
Specificity Phospho-Trk A (Y496) Polyclonal Antibody detects endogenous levels of Trk A protein only when phosphorylated at Y496.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name NTRK1
Accession No. P04629 Q3UFB7 P35739
Alternate Names NTRK1; MTC; TRK; TRKA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A;
Description neurotrophic receptor tyrosine kinase 1(NTRK1) Homo sapiens This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,Endocytosis,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,Neurotrophin,Pathways in cancer,Thyroid cancer,
Protein Expression Brain,Colon,Peripheral blood,
Subcellular Localization endosome,early endosome,late endosome,plasma membrane,integral component of plasma membrane,cell surface,axon,dendrite,cytoplasmic vesicle,early endosome membrane,late endosome membrane,neuronal cell body,
Protein Function Both isoforms have similar biological properties,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Chromosomal aberrations involving NTRK1 are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Intrachromosomal rearrangement that links the protein kinase domain of NTRK1 to the 5'-end of the TPR gene forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the C-terminus of the NTRK1 protein.,disease:Chromosomal aberrations involving NTRK1 are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Translocation t(1;3)(q21;q11) with TFG generates the TRKT3 (TRK-T3) transcript by fusing TFG to the 3'-end of NTRK1; a rearrangement with TPM3 generates the TRK transcript by fusing TPM3 to the 3'-end of NTRK1.,disease:Defects in NTRK1 are a cause of congenital insensitivity to pain with anhidrosis (CIPA) [MIM:256800]. CIPA is characterized by a congenital insensitivity to pain, anhidrosis (absence of sweating), absence of reaction to noxious stimuli, self-mutilating behavior, and mental retardation. This rare autosomal recessive disorder is also known as congenital sensory neuropathy with anhidrosis or hereditary sensory and autonomic neuropathy type IV or familial dysautonomia type II.,domain:The extracellular domain mediates interaction with NGFR.,domain:The transmembrane domain mediates interaction with KIDINS220.,function:Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.,PTM:Ligand-mediated auto-phosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 LRR (leucine-rich) repeats.,subcellular location:Endocytosed to the endosomes upon treatment of cells with NGF.,subunit:Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with KIDINS220 and NGFR. Can form a ternary complex with NGFR and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.,tissue specificity:Isoform TrkA-II is primarily expressed in neuronal cells; isoform TrkA-I is found in non-neuronal tissues.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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