ITT0055
ITT0055
- Catalog: ITT0055
- Gene/Protein: ABHD12
- Product Description: Immunotag™ ABHD12 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ABHD12 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from ABHD12, at AA range: 200-280 |
| Specificity | ABHD12 Polyclonal Antibody detects endogenous levels of ABHD12 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ABHD12 |
| Accession No. | Q8N2K0 Q99LR1 Q6AYT7 |
| Alternate Names | ABHD12; C20orf22; Monoacylglycerol lipase ABHD12; 2-arachidonoylglycerol hydrolase; Abhydrolase domain-containing protein 12 |
| Description | abhydrolase domain containing 12(ABHD12) Homo sapiens This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011], |
| Protein Expression | Cerebellum,Kidney,Ovarian carcinoma,Pancreas,Testis, |
| Subcellular Localization | plasma membrane,integral component of membrane,AMPA glutamate receptor complex, |
| Protein Function | catalytic activity:Hydrolyzes glycerol monoesters of long-chain fatty acids.,function:Has 2-arachidonoylglycerol hydrolase activity (By similarity). May be a regulator of endocannabinoid signaling pathways.,PTM:Glycosylated.,similarity:Belongs to the serine esterase family., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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