ITT0083
ITT0083
- Catalog: ITT0083
- Gene/Protein: CHRNA5
- Product Description: Immunotag™ AChRα5 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | AChRα5 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat,Monkey |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from the Internal region of human AChRα5 |
Specificity | AChRα5 Polyclonal Antibody detects endogenous levels of AChRα5 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | CHRNA5 |
Accession No. | P30532 Q2MKA5 P20420 |
Alternate Names | CHRNA5; NACHRA5; Neuronal acetylcholine receptor subunit alpha-5 |
Description | cholinergic receptor nicotinic alpha 5 subunit(CHRNA5) Homo sapiens The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010], |
Protein Expression | Eye, |
Subcellular Localization | plasma membrane,acetylcholine-gated channel complex,integral component of membrane,cell junction,postsynaptic membrane, |
Protein Function | disease:Genetic variations in CHRNA5 may be associated with susceptibility to lung cancer type 2 (LNCR2) [MIM:612052].,function:After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta)., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |