ITT0168
ITT0168
- Catalog: ITT0168
- Gene/Protein: AKAP8
- Product Description: Immunotag™ AKAP 95 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | AKAP 95 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from AKAP 95, at AA range: 300-380 |
| Specificity | AKAP 95 Polyclonal Antibody detects endogenous levels of AKAP 95 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | AKAP8 |
| Accession No. | O43823 Q9DBR0 Q63014 |
| Alternate Names | AKAP8; AKAP95; A-kinase anchor protein 8; AKAP-8; A-kinase anchor protein 95 kDa; AKAP 95 |
| Description | A-kinase anchoring protein 8(AKAP8) Homo sapiens This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011], |
| Protein Expression | Cerebellum,Epithelium,Testis,Uterus, |
| Subcellular Localization | condensed chromosome,female pronucleus,nucleus,nucleoplasm,nucleolus,mitochondrion,Golgi apparatus,membrane,nuclear matrix, |
| Protein Function | function:Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II).,similarity:Belongs to the AKAP95 family.,subcellular location:Associated with the nuclear matrix. Redistributed and detached from condensed chromatin during mitosis.,subunit:Binds to dimeric RII-alpha regulatory subunit of PKA during mitosis.,tissue specificity:Highly expressed in heart, liver, skeletal muscle, kidney and pancreas., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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