ITT0340
ITT0340
- Catalog: ITT0340
- Gene/Protein: ARRDC3
- Product Description: Immunotag™ ARRDC3 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ARRDC3 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from ARRDC3, at AA range: 340-420 |
| Specificity | ARRDC3 Polyclonal Antibody detects endogenous levels of ARRDC3 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ARRDC3 |
| Accession No. | Q96B67 Q7TPQ9 Q6TXF1 |
| Alternate Names | ARRDC3; KIAA1376; Arrestin domain-containing protein 3; TBP-2-like inducible membrane protein; TLIMP |
| Description | arrestin domain containing 3(ARRDC3) Homo sapiens This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016], |
| Protein Expression | Brain,Placenta,Uterus, |
| Subcellular Localization | lysosome,endosome,early endosome,plasma membrane, |
| Protein Function | induction:By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by PMA (phorbol myristate acetate) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist).,similarity:Belongs to the arrestin family.,subcellular location:Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis.,subunit:Does not bind TXN (thioredoxin).,tissue specificity:Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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