ITT0391
ITT0391
- Catalog: ITT0391
- Gene/Protein: ATG16L1
- Product Description: Immunotag™ Atg16 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | ATG16 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Atg16 . at AA range: 60-140 |
| Specificity | Atg16 Polyclonal Antibody detects endogenous levels of Atg16 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | ATG16L1 |
| Accession No. | Q676U5 Q8C0J2 |
| Alternate Names | ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1 |
| Description | autophagy related 16 like 1(ATG16L1) Homo sapiens The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010], |
| Protein Expression | Brain,Colon,Epithelium,Fetal brain,Human lung,Mammary gland,Placenta,Small |
| Subcellular Localization | autophagosome membrane,autophagosome,cytosol,axoneme,pre-autophagosomal structure membrane, |
| Protein Function | disease:Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10) [MIM:611081]. IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease.,function:Plays an essential role in autophagy.,sequence caution:Wrong choice of CDS.,similarity:Belongs to the WD repeat ATG16 family.,similarity:Contains 7 WD repeats.,subcellular location:Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.,subunit:Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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