ITT0396
ITT0396
- Catalog: ITT0396
- Gene/Protein: ATG4D
- Product Description: Immunotag™ Atg4D Polyclonal Antibody
385.0000
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Antibody Specification | |
Datasheet | |
Target Protein | ATG4D |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from the Internal region of human Atg4D. |
Specificity | Atg4D Polyclonal Antibody detects endogenous levels of Atg4D protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | ATG4D |
Accession No. | Q86TL0 Q8BGV9 |
Alternate Names | ATG4D; APG4D; AUTL4; Cysteine protease ATG4D; AUT-like 4 cysteine endopeptidase; Autophagin-4; Autophagy-related cysteine endopeptidase 4; Autophagy-related protein 4 homolog D |
Description | autophagy related 4D cysteine peptidase(ATG4D) Homo sapiens Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], |
Cell Pathway/ Category | Regulation of autophagy, |
Protein Expression | Fetal liver,Lung,Ovary,Stomach mucosa,Uterus, |
Subcellular Localization | cytoplasm,mitochondrial matrix,cytosol, |
Protein Function | enzyme regulation:Inhibited by N-ethylmaleimide.,function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Mainly expressed in skeletal muscle and, to a lower extent, in testis., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |