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ITT0682

ITT0682
ITT0682
ITT0682
  • Catalog: ITT0682
  • Gene/Protein: CTSE
  • Product Description: Immunotag™ Cathepsin E Polyclonal Antibody
334.0000
Price in reward points: 334

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Immunotag™ Cathepsin E Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CathEPSin E
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from the Internal region of human Cathepsin E
Specificity Cathepsin E Polyclonal Antibody detects endogenous levels of Cathepsin E protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CTSE
Accession No. P14091 P70269 P16228
Alternate Names CTSE; Cathepsin E
Description cathepsin E(CTSE) Homo sapiens This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015],
Cell Pathway/ Category Lysosome,
Protein Expression Brain,Erythrocyte,Gastric adenocarcinoma,Gastric mucosa,Intestine,Stomach,
Subcellular Localization endosome,extracellular exosome,
Protein Function catalytic activity:Similar to cathepsin D, but slightly broader specificity.,function:May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.,PTM:Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.,PTM:Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57.,similarity:Belongs to the peptidase A1 family.,subcellular location:The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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