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ITT0845

ITT0845-2
ITT0845
ITT0845-2
ITT0845
ITT0845
  • Catalog: ITT0845
  • Gene/Protein: CUX1
  • Product Description: Immunotag™ CUX1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CUX1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CUX1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human CUTL1. AA range:10-59
Specificity CUX1 Polyclonal Antibody detects endogenous levels of CUX1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CUX1
Accession No. P39880/Q13948
Alternate Names CUX1; CUTL1; Homeobox protein cut-like 1; CCAAT displacement protein; CDP; Homeobox protein cux-1; CUX1; CUTL1; Protein CASP
Description cut like homeobox 1(CUX1) Homo sapiens The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011],
Protein Expression Colon,Duodenum,Liver,Umbilical vein,
Subcellular Localization Golgi membrane,nucleus,nucleoplasm,Golgi apparatus,cytosol,integral component of Golgi membrane,
Protein Function Additional isoforms seem to exist,function:May be involved in intra-Golgi retrograde transport.,function:Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer.,miscellaneous:Asn-1290 may participate in regulating DNA-binding activity by promoting homo- and heterodimerization.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CASP family.,similarity:Belongs to the CUT homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 3 CUT DNA-binding domains.,subunit:Homodimer; disulfide-linked. Interacts with GOLGA5.,subunit:Interacts with BANP.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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