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ITT0909

ITT0909
ITT0909
ITT0909
  • Gene/Protein: CHAT
  • Product Description: Immunotag™ Choactase Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ Choactase Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Choactase
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from the Internal region of human Choactase
Specificity Choactase Polyclonal Antibody detects endogenous levels of Choactase protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CHAT
Accession No. P28329 Q03059 P32738
Alternate Names CHAT; Choline O-acetyltransferase; CHOACTase; ChAT; Choline acetylase
Description choline O-acetyltransferase(CHAT) Homo sapiens This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010],
Cell Pathway/ Category Glycerophospholipid metabolism,
Protein Expression Brain,Lymphocyte,Placenta,Spinal cord,
Subcellular Localization nucleus,cytoplasm,cytosol,presynapse,
Protein Function catalytic activity:Acetyl-CoA + choline = CoA + O-acetylcholine.,disease:Defects in CHAT are the cause of congenital myasthenic syndrome with episodic apnea (CMSEA) [MIM:254210]; formerly known as familial infantile myasthenia gravis 2 (FIMG2). CMSEA is an autosomal recessive congenital myasthenic syndrome. Patients have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement.,function:Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.,online information:Choline acetyltransferase entry,similarity:Belongs to the carnitine/choline acetyltransferase family.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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