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ITT0914

ITT0914
ITT0914
ITT0914
  • Catalog: ITT0914
  • Gene/Protein: CHP1
  • Product Description: Immunotag™ CHP Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ CHP Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein CHP
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from the Internal region of human CHP
Specificity CHP Polyclonal Antibody detects endogenous levels of CHP protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CHP1
Accession No. Q99653 P61022 P61023
Alternate Names CHP1; CHP; Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22
Description calcineurin like EF-hand protein 1(CHP1) Homo sapiens This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category MAPK_ERK_Growth,MAPK_G_Protein,Calcium,Oocyte meiosis,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,WNT,WNT-T CELLAxon guidance,VEGF,Natural killer cell mediated cytotoxicity,T_Cell_Receptor,B_Cell_Antigen,Long-term potentiation,Alzheimer's disease,Amyotrophic lateral sclerosis (ALS),
Protein Expression B-cell,Brain,Uterus,
Subcellular Localization Golgi membrane,nucleus,cytoplasm,endoplasmic reticulum,endoplasmic reticulum-Golgi intermediate compartment,cytosol,plasma membrane,focal adhesion,microtubule cytoskeleton,transport vesicle,extracellular exosome,
Protein Function function:Required for constitutive membrane traffic. Inhibits GTPase-stimulated Na(+)/H(+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1.,PTM:Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic.,PTM:Phosphorylated; decreased phosphorylation is associated with an increase in exchange activity. The phosphorylation state may regulate the binding to NHE1.,similarity:Contains 4 EF-hand domains.,subunit:Monomer (By similarity). Specifically binds to SLC9A1/NHE1 at a domain that is critical for growth factor stimulation of exchange activity.,tissue specificity:Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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