ITT0915
ITT0915
- Catalog: ITT0915
- Gene/Protein: CHP2
- Product Description: Immunotag™ CHP2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | CHP2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from CHP2, at AA range: 70-150 |
| Specificity | CHP2 Polyclonal Antibody detects endogenous levels of CHP2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CHP2 |
| Accession No. | O43745 Q9D869 Q810D1 |
| Alternate Names | CHP2; HCA520; Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520 |
| Description | calcineurin like EF-hand protein 2(CHP2) Homo sapiens This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013], |
| Cell Pathway/ Category | MAPK_ERK_Growth,MAPK_G_Protein,Calcium,Oocyte meiosis,Apoptosis_Inhibition,Apoptosis_Mitochondrial,Apoptosis_Overview,WNT,WNT-T CELLAxon guidance,VEGF,Natural killer cell mediated cytotoxicity,T_Cell_Receptor,B_Cell_Antigen,Long-term potentiation,Alzheimer's disease,Amyotrophic lateral sclerosis (ALS), |
| Protein Expression | Caudate nucleus,Colon,Hepatoma, |
| Subcellular Localization | nucleus,cytoplasm,plasma membrane, |
| Protein Function | function:Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death.,similarity:Contains 4 EF-hand domains.,subunit:Binds to SLC9A1/NHE1.,tissue specificity:Expressed in malignantly transformed cells but not detected in normal tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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