ITT0931
ITT0931
- Catalog: ITT0931
- Gene/Protein: CIT
- Product Description: Immunotag™ Citron Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | Citron |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human CTRO. AA range:1011-1060 |
Specificity | Citron Polyclonal Antibody detects endogenous levels of Citron protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | CIT |
Accession No. | O14578 P49025 |
Alternate Names | CIT; CRIK; KIAA0949; STK21; Citron Rho-interacting kinase; CRIK; Serine/threonine-protein kinase 21 |
Description | citron rho-interacting serine/threonine kinase(CIT) Homo sapiens This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011], |
Protein Expression | Brain,Epithelium, |
Subcellular Localization | intracellular,cytosol,plasma membrane,membrane,Golgi cisterna,neuronal cell body, |
Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 CNH domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |