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ITT0931

  • Gene/Protein: CIT
  • Product Description: Immunotag™ Citron Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

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ITT0931

Immunotag™ Citron Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Citron
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human CTRO. AA range:1011-1060
Specificity Citron Polyclonal Antibody detects endogenous levels of Citron protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CIT
Accession No. O14578 P49025
Alternate Names CIT; CRIK; KIAA0949; STK21; Citron Rho-interacting kinase; CRIK; Serine/threonine-protein kinase 21
Description citron rho-interacting serine/threonine kinase(CIT) Homo sapiens This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],
Protein Expression Brain,Epithelium,
Subcellular Localization intracellular,cytosol,plasma membrane,membrane,Golgi cisterna,neuronal cell body,
Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 CNH domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subunit:Directly interacts with KIF14 depending on the activation state (stronger interaction with the kinase-dead form). Homodimer.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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