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ITT0955

ITT0955
ITT0955
ITT0955
  • Catalog: ITT0955
  • Gene/Protein: CLDN6
  • Product Description: Immunotag™ Claudin-6 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ Claudin-6 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Claudin-6
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human CLDN6. AA range:81-130
Specificity Claudin-6 Polyclonal Antibody detects endogenous levels of Claudin-6 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name CLDN6
Accession No. P56747 Q9Z262
Alternate Names CLDN6; Claudin-6; Skullin
Description claudin 6(CLDN6) Homo sapiens Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010],
Cell Pathway/ Category Cell adhesion molecules (CAMs),Tight junction,Leukocyte transendothelial migration,
Protein Expression Placenta,
Subcellular Localization bicellular tight junction,integral component of membrane,apicolateral plasma membrane,
Protein Function function:Plays a major role in tight junction-specific obliteration of the intercellular space.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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