ITT1007
ITT1007
- Catalog: ITT1007
- Gene/Protein: CFL1/CFL2
- Product Description: Immunotag™ Cofilin Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CofIL-in |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from Cofilin, at AA range: 30-110 |
| Specificity | Cofilin Polyclonal Antibody detects endogenous levels of Cofilin protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CFL1/CFL2 |
| Accession No. | P23528/Q9Y281 P45592 |
| Alternate Names | CFL1; CFL; Cofilin-1; 18 kDa phosphoprotein; p18; Cofilin; non-muscle isoform; CFL2; Cofilin-2; Cofilin, muscle isoform |
| Description | cofilin 1(CFL1) Homo sapiens The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004], |
| Cell Pathway/ Category | Axon guidance,Fc gamma R-mediated phagocytosis,Regulates Actin and Cytoskeleton, |
| Protein Expression | B-cell lymphoma,Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Lung,Ovary,Placenta,Platelet |
| Subcellular Localization | extracellular space,nucleus,cytoplasm,focal adhesion,actin cytoskeleton,membrane,nuclear matrix,extracellular matrix,lamellipodium membrane,vesicle,ruffle membrane,extracellular exosome, |
| Protein Function | function:Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.,online information:Cofilin entry,PTM:Phosphorylated on Ser-3 in resting cells.,similarity:Belongs to the actin-binding proteins ADF family.,similarity:Contains 1 ADF-H domain.,subcellular location:Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.,tissue specificity:Widely distributed in various tissues., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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