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ITT1049

ITT1049
ITT1049
ITT1049
  • Catalog: ITT1049
  • Gene/Protein: GJC2
  • Product Description: Immunotag™ Connexin 47 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ Connexin 47 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Connexin 47
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human CXG2. AA range:21-70
Specificity Connexin 47 Polyclonal Antibody detects endogenous levels of Connexin 47 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name GJC2
Accession No. Q5T442 Q8BQU6
Alternate Names GJC2; GJA12; Gap junction gamma-2 protein; Connexin-46.6; Cx46.6; Connexin-47; Cx47; Gap junction alpha-12 protein
Description gap junction protein gamma 2(GJC2) Homo sapiens This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1. [provided by RefSeq, Jul 2008],
Protein Expression Brain,Chondrosarcoma,Corpus callosum,
Subcellular Localization connexon complex,integral component of membrane,myelin sheath,
Protein Function caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in GJC2 are the cause of Leukodystrophy hypomyelinating type 2 (HLD2) [MIM:608804]; also known as Pelizaeus-Merzbacher-like disease autosomal recessive type 1. HLD2 is an autosomal recessive hypomyelinating leukodystrophy characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria and progressive spasticity.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins. Interacts with TJP1.,tissue specificity:Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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