ITT1104
ITT1104
- Catalog: ITT1104
- Gene/Protein: CREB3L2
- Product Description: Immunotag™ CREB3L2 Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | CREB3L2 |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse,Rat |
| Host Species | Rabbit |
| Immunogen | Synthesized peptide derived from CREB3L2, at AA range: 240-320 |
| Specificity | CREB3L2 Polyclonal Antibody detects endogenous levels of CREB3L2 protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CREB3L2 |
| Accession No. | Q70SY1 Q8BH52 Q6QDP7 |
| Alternate Names | CREB3L2; BBF2H7; Cyclic AMP-responsive element-binding protein 3-like protein 2; cAMP-responsive element-binding protein 3-like protein 2; BBF2 human homolog on chromosome 7 |
| Description | cAMP responsive element binding protein 3 like 2(CREB3L2) Homo sapiens This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011], |
| Cell Pathway/ Category | Melanogenesis,Huntington's disease,Prostate cancer, |
| Protein Expression | Brain,Cervix,Low grade fibromyxoid sarcoma,Lung,Pla |
| Subcellular Localization | nucleus,nucleoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,integral component of membrane, |
| Protein Function | disease:A chromosomal rearrangement involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.,function:Transcriptional activator that may act during endoplasmic reticulum stress late phase by activating unfolded protein response target genes. May play a role in preventing accumulation of unfolded proteins in damaged neurons. In vitro, binds to the cAMP response element (CRE) and activates transcription through CRE.,PTM:Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2).,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. ATF subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.,subunit:Binds DNA as a dimer.,tissue specificity:Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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