ITT1181
ITT1181
- Catalog: ITT1181
- Gene/Protein: CCNG1
- Product Description: Immunotag™ Cyclin G Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | Cyclin G |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from Cyclin G, at AA range: 130-210 |
Specificity | Cyclin G Polyclonal Antibody detects endogenous levels of Cyclin G protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | CCNG1 |
Accession No. | P51959 P51945 P39950 |
Alternate Names | CCNG1; CCNG; CYCG1; Cyclin-G1; Cyclin-G |
Description | cyclin G1(CCNG1) Homo sapiens The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008], |
Cell Pathway/ Category | p53, |
Protein Expression | Eye,Fetal spleen,Fibroblast,Human endometrium carcinoma cell line,Mammary gland,Prostate, |
Subcellular Localization | nucleoplasm, |
Protein Function | developmental stage:Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.,function:May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.,induction:Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.,similarity:Belongs to the cyclin family. Cyclin G subfamily.,subcellular location:DNA replication foci after DNA damage.,tissue specificity:High levels in skeletal muscle, ovary, kidney and colon., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |