ITT1606
ITT1606
- Catalog: ITT1606
- Gene/Protein: ERAP1
- Product Description: Immunotag™ ERAP1 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | ERAP1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,IHC-p,IF,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from ERAP1, at AA range: 410-490 |
Specificity | ERAP1 Polyclonal Antibody detects endogenous levels of ERAP1 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | ERAP1 |
Accession No. | Q9NZ08 Q9EQH2 Q9JJ22 |
Alternate Names | ERAP1; APPILS; ARTS1; KIAA0525; Endoplasmic reticulum aminopeptidase 1; ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP; Type 1 tumor necrosis facto |
Description | endoplasmic reticulum aminopeptidase 1(ERAP1) Homo sapiens The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010], |
Protein Expression | Brain,Leukocyte,Liver,Testis,White adipose tissue, |
Subcellular Localization | extracellular region,extracellular space,endoplasmic reticulum,endoplasmic reticulum lumen,endoplasmic reticulum membrane,cytosol,plasma membrane,membrane,integral component of membrane,extracellular exosome, |
Protein Function | catalytic activity:Release of an N-terminal amino acid, Xaa-|-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Met, Cys and Phe.,caution:It is uncertain whether Met-1 or Met-13 is the initiator.,cofactor:Binds 1 zinc ion per subunit.,function:Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.,induction:By IFN-gamma.,PTM:N-glycosylated.,similarity:Belongs to the peptidase M1 family.,subunit:Monomer. May also exist as a heterodimer; with ERAP2.,tissue specificity:Ubiquitous., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |