ITT1834
ITT1834
- Catalog: ITT1834
- Gene/Protein: GAK
- Product Description: Immunotag™ GAK Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | GAK |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GAK. AA range:101-150 |
| Specificity | GAK Polyclonal Antibody detects endogenous levels of GAK protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GAK |
| Accession No. | O14976 Q99KY4 |
| Alternate Names | GAK; Cyclin-G-associated kinase |
| Description | cyclin G associated kinase(GAK) Homo sapiens In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015], |
| Protein Expression | Brain,Cerebellum,Fibroblast,Ovary,PCR rescued clones,Placenta,Testis, |
| Subcellular Localization | Golgi apparatus,cytosol,focal adhesion,membrane,vesicle,intracellular membrane-bounded organelle,perinuclear region of cytoplasm, |
| Protein Function | catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 J domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focals adhesions.,tissue specificity:Ubiquitous. Highest in testis., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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