ITT1918
ITT1918
- Catalog: ITT1918
- Gene/Protein: GANAB
- Product Description: Immunotag™ Glucosidase IIα Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
|
| Target Protein | Glucosidase IIα |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IHC-p,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GANAB. AA range:242-291 |
| Specificity | Glucosidase IIα Polyclonal Antibody detects endogenous levels of Glucosidase IIα protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | GANAB |
| Accession No. | Q14697 Q8BHN3 |
| Alternate Names | GANAB; G2AN; KIAA0088; Neutral alpha-glucosidase AB; Alpha-glucosidase 2; Glucosidase II subunit alpha |
| Description | glucosidase II alpha subunit(GANAB) Homo sapiens This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016], |
| Cell Pathway/ Category | N-Glycan biosynthesis, |
| Protein Expression | Bone marrow,Brain,Cajal-Retzius cell,Cervix,Lymph,Uterus, |
| Subcellular Localization | endoplasmic reticulum lumen,Golgi apparatus,membrane,integral component of membrane,glucosidase II complex,extracellular matrix,melanosome,extracellular exosome, |
| Protein Function | catalytic activity:Hydrolysis of terminal (1->3)-alpha-D-glucosidic links in (1->3)-alpha-D-glucans.,function:Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.,pathway:Glycan metabolism; N-glycan metabolism.,similarity:Belongs to the glycosyl hydrolase 31 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Heterodimer of a catalytic alpha subunit (GANAB) and a beta subunit (PRKCSH). Binds glycosylated PTPRC.,tissue specificity:Detected in placenta., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
| English_US |
|
| Danish |
|
| Dutch |
|
| English_UK |
|
| French |
|
| German |
|
| Spanish |
|
| Norwegian |
|
| Portuguese |
|
| Finnish |
|
| Swedish |
|
| Polish |
|