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ITT2043

  • Gene/Protein: GPT2
  • Product Description: Immunotag™ GPT2 Polyclonal Antibody
  • 280.0000
    Price in reward points: 294

    Available Options

ITT2043

Immunotag™ GPT2 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein GPT2
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from GPT2 . at AA range: 190-270
Specificity GPT2 Polyclonal Antibody detects endogenous levels of GPT2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name GPT2
Accession No. Q8TD30 Q8BGT5
Alternate Names GPT2; AAT2; ALT2; Alanine aminotransferase 2; ALT2; Glutamate pyruvate transaminase 2; GPT 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2
Description glutamic--pyruvic transaminase 2(GPT2) Homo sapiens This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Cell Pathway/ Category Alanine, aspartate and glutamate metabolism,
Protein Expression Adipose tissue,Hippocampus,Lung,
Subcellular Localization mitochondrion,mitochondrial matrix,
Protein Function catalytic activity:L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.,cofactor:Pyridoxal phosphate.,pathway:Amino-acid degradation; L-alanine degradation via transaminase pathway; pyruvate from L-alanine: step 1/1.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.,subunit:Homodimer.,tissue specificity:Expressed at high levels in muscle, adipose tissue, kidney and brain and at lower levels in the liver and breast.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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