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ITT2069

ITT2069
  • Catalog: ITT2069
  • Gene/Protein: GRK4
  • Product Description: Immunotag™ GRK 4 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ GRK 4 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein GRK 4
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IHC-p,ELISA
Recommended Dilution Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen Synthesized peptide derived from GRK 4 . at AA range: 10-90
Specificity GRK 4 Polyclonal Antibody detects endogenous levels of GRK 4 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name GRK4
Accession No. P32298 O70291
Alternate Names GRK4; GPRK2L; GPRK4; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; ITI1
Description G protein-coupled receptor kinase 4(GRK4) Homo sapiens This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013],
Cell Pathway/ Category Chemokine,Endocytosis,
Protein Expression Brain,Kidney,Testis,
Subcellular Localization cytosol,cell cortex,dendrite,neuronal cell body,photoreceptor disc membrane,
Protein Function catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Testis, and in a lower extent in other tissues including brain cortex and striatum.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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