ITT2069
ITT2069
- Catalog: ITT2069
- Gene/Protein: GRK4
- Product Description: Immunotag™ GRK 4 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | GRK 4 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IHC-p,ELISA |
Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from GRK 4 . at AA range: 10-90 |
Specificity | GRK 4 Polyclonal Antibody detects endogenous levels of GRK 4 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | GRK4 |
Accession No. | P32298 O70291 |
Alternate Names | GRK4; GPRK2L; GPRK4; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; ITI1 |
Description | G protein-coupled receptor kinase 4(GRK4) Homo sapiens This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013], |
Cell Pathway/ Category | Chemokine,Endocytosis, |
Protein Expression | Brain,Kidney,Testis, |
Subcellular Localization | cytosol,cell cortex,dendrite,neuronal cell body,photoreceptor disc membrane, |
Protein Function | catalytic activity:ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.,function:Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Testis, and in a lower extent in other tissues including brain cortex and striatum., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |