ITT2315
ITT2315
- Catalog: ITT2315
- Gene/Protein: IL15RA
- Product Description: Immunotag™ IL-15Rα Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | IL-15Rα |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Rat |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human IL15RA. AA range:99-148 |
| Specificity | IL-15Rα Polyclonal Antibody detects endogenous levels of IL-15Rα protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | IL15RA |
| Accession No. | Q13261 Q60819 |
| Alternate Names | IL15RA; Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD antigen CD215 |
| Description | interleukin 15 receptor subunit alpha(IL15RA) Homo sapiens This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Jak_STAT,Intestinal immune network for IgA production, |
| Protein Expression | Bone marrow stroma,Brain,Ovary,Pooled, |
| Subcellular Localization | Golgi membrane,extracellular space,endoplasmic reticulum membrane,plasma membrane,integral component of membrane,cytoplasmic vesicle membrane,cytoplasmic vesicle,nuclear membrane, |
| Protein Function | function:Receptor for interleukin-15. Expression of different isoforms may alter or interfere with signal transduction. Isoform 6, isoform 7, isoform 8 and isoform 9 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK.,PTM:A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor.,PTM:N-glycosylated and O-glycosylated.,PTM:Phosphorylated by activated SYK.,similarity:Contains 1 Sushi (CCP/SCR) domain.,subcellular location:Isoform 6, isoform 7, isoform 8 and isoform 9 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.,subcellular location:Mainly found associated with the nuclear membrane.,subunit:The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK.,tissue specificity:Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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