ITT2674
ITT2674
- Catalog: ITT2674
- Gene/Protein: MC2R
- Product Description: Immunotag™ MC2-R Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MC2-R |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | WB,IF,ELISA |
| Recommended Dilution | Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human,Mouse |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ACTHR. AA range:248-297 |
| Specificity | MC2-R Polyclonal Antibody detects endogenous levels of MC2-R protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | MC2R |
| Accession No. | Q01718 Q64326 |
| Alternate Names | MC2R; ACTHR; Adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; Adrenocorticotropin receptor; Melanocortin receptor 2; MC2-R |
| Description | melanocortin 2 receptor(MC2R) Homo sapiens MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014], |
| Cell Pathway/ Category | Neuroactive ligand-receptor interaction, |
| Protein Expression | Adrenal gland,Skin, |
| Subcellular Localization | cytoplasm,plasma membrane,integral component of plasma membrane,integral component of membrane, |
| Protein Function | disease:Defects in MC2R are the cause of glucocorticoid deficiency type 1 (GCCD1) [MIM:202200]; also known as familial glucocorticoid deficiency type 1 (FGD1). GCCD1 is an autosomal recessive disorder due to congenital insensitivity or resistance to adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency.,function:Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with FALP/MRAP.,tissue specificity:Melanocytes and corticoadrenal tissue., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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