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ITT2729

ITT2729-2
ITT2729-3
ITT2729
ITT2729-2
ITT2729-3
ITT2729
ITT2729
  • Catalog: ITT2729
  • Gene/Protein: OPN4
  • Product Description: Immunotag™ Melanopsin Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ Melanopsin Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein Melanopsin
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human OPN4. AA range:429-478
Specificity Melanopsin Polyclonal Antibody detects endogenous levels of Melanopsin protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name OPN4
Accession No. Q9UHM6 Q9QXZ9
Alternate Names OPN4; MOP; Melanopsin; Opsin-4
Description opsin 4(OPN4) Homo sapiens Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by Ref
Protein Expression Brain cortex,
Subcellular Localization plasma membrane,integral component of plasma membrane,integral component of membrane,
Protein Function caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal.,similarity:Belongs to the G-protein coupled receptor 1 family.,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.,subcellular location:Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells.,tissue specificity:Eye. Expression is restricted within the ganglion and amacrine cell layers of the retina.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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