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ITT2747

ITT2747
ITT2747-2
ITT2747
ITT2747-2
ITT2747
  • Catalog: ITT2747
  • Gene/Protein: GRM7
  • Product Description: Immunotag™ mGluR-7 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ mGluR-7 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein mGlu-R7
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,IF,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from mGluR-7, at AA range: 840-920
Specificity mGluR-7 Polyclonal Antibody detects endogenous levels of mGluR-7 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name GRM7
Accession No. Q14831 Q68ED2 P35400
Alternate Names GRM7; GPRC1G; MGLUR7; Metabotropic glutamate receptor 7; mGluR7
Description glutamate metabotropic receptor 7(GRM7) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found
Cell Pathway/ Category Neuroactive ligand-receptor interaction,
Protein Expression Brain,Hippocampus,Testicle,
Subcellular Localization plasma membrane,integral component of plasma membrane,cell cortex,integral component of membrane,axon,dendrite,asymmetric synapse,presynaptic membrane,dendritic shaft,receptor complex,postsynaptic membrane,presynaptic ac
Protein Function function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with PICK1.,tissue specificity:Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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