ITT2765
ITT2765
- Catalog: ITT2765
- Gene/Protein: CCL3
- Product Description: Immunotag™ MIP-1α Polyclonal Antibody
385.0000
Price in reward points: 385
| Antibody Specification | |
| Datasheet | 
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| Target Protein | MIP-1α |
| Clonality | Polyclonal |
| Storage/Stability | -20°C/1 year |
| Application | IHC-p,ELISA |
| Recommended Dilution | Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications. |
| Concentration | 1 mg/ml |
| Reactive Species | Human |
| Host Species | Rabbit |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MIP-1alpha. AA range:26-75 |
| Specificity | MIP-1α Polyclonal Antibody detects endogenous levels of MIP-1α protein. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
| Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Gene Name | CCL3 |
| Accession No. | P10147 P10855 |
| Alternate Names | CCL3; G0S19-1; MIP1A; SCYA3; C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha protein |
| Description | C-C motif chemokine ligand 3(CCL3) Homo sapiens This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010], |
| Cell Pathway/ Category | Cytokine-cytokine receptor interaction,Chemokine,Toll_Like, |
| Protein Expression | Brain,Leukocyte,Lymphocyte,Natural killer cell,T-cell, |
| Subcellular Localization | extracellular region,extracellular space,intracellular,cytoplasm,cytosol, |
| Protein Function | function:Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).,induction:By TPA or PHA (TPA = 12-O-tetradecanoyl phorbol-13 acetate (tumor promoter); PHA = phytohemagglutinin (T-cell mitogen)).,online information:Macrophage inflammatory protein entry,PTM:N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Self-associates. Also heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69)., |
| Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |
| Material Safety Data Sheet | |
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