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ITT2820

ITT2820
  • Catalog: ITT2820
  • Gene/Protein: NOX1
  • Product Description: Immunotag™ Mox1 Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ Mox1 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein MOX-1
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse
Host Species Rabbit
Immunogen The antiserum was produced against synthesized peptide derived from human NOX1. AA range:436-485
Specificity Mox1 Polyclonal Antibody detects endogenous levels of Mox1 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name NOX1
Accession No. Q9Y5S8 Q8CIZ9
Alternate Names NOX1; MOX1; NOH1; NADPH oxidase 1; NOX-1; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1
Description NADPH oxidase 1(NOX1) Homo sapiens This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012],
Cell Pathway/ Category Leukocyte transendothelial migration,
Protein Expression Colon epithelium,
Subcellular Localization early endosome,plasma membrane,integral component of membrane,cell junction,NADPH oxidase complex,invadopodium membrane,
Protein Function cofactor:FAD .,cofactor:NADP .,enzyme regulation:The oxidase activity is potentiated by NOXA1 and NOXO1.,function:NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1.,tissue specificity:NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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