ITT2820
ITT2820
- Catalog: ITT2820
- Gene/Protein: NOX1
- Product Description: Immunotag™ Mox1 Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | MOX-1 |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | WB,ELISA |
Recommended Dilution | Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse |
Host Species | Rabbit |
Immunogen | The antiserum was produced against synthesized peptide derived from human NOX1. AA range:436-485 |
Specificity | Mox1 Polyclonal Antibody detects endogenous levels of Mox1 protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | NOX1 |
Accession No. | Q9Y5S8 Q8CIZ9 |
Alternate Names | NOX1; MOX1; NOH1; NADPH oxidase 1; NOX-1; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1 |
Description | NADPH oxidase 1(NOX1) Homo sapiens This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012], |
Cell Pathway/ Category | Leukocyte transendothelial migration, |
Protein Expression | Colon epithelium, |
Subcellular Localization | early endosome,plasma membrane,integral component of membrane,cell junction,NADPH oxidase complex,invadopodium membrane, |
Protein Function | cofactor:FAD .,cofactor:NADP .,enzyme regulation:The oxidase activity is potentiated by NOXA1 and NOXO1.,function:NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,subunit:NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1.,tissue specificity:NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |