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ITT3573

ITT3573
ITT3573-2
ITT3573
ITT3573-2
ITT3573
  • Gene/Protein: PAK7
  • Product Description: Immunotag™ PAK5 Polyclonal Antibody
280.0000
Price in reward points: 294

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Immunotag™ PAK5 Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PAK5
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application WB,IHC-p,ELISA
Recommended Dilution Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from PAK5, at AA range: 630-710
Specificity PAK5 Polyclonal Antibody detects endogenous levels of PAK5 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PAK7
Accession No. Q9P286 Q8C015 D4A280
Alternate Names PAK7; KIAA1264; PAK5; Serine/threonine-protein kinase PAK 7; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7
Description p21 (RAC1) activated kinase 5(PAK5) Homo sapiens The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
Cell Pathway/ Category ErbB_HER,Axon guidance,Focal adhesion,T_Cell_Receptor,Regulates Actin and Cytoskeleton,Renal cell carcinoma,
Protein Expression Brain,Tongue,
Subcellular Localization nucleus,cytoplasm,mitochondrion,
Protein Function catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:The activated kinase acts on a variety of targets.,PTM:Autophosphorylated when activated by CDC42/p21.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1.,tissue specificity:Predominantly expressed in brain.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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