ITT3787
ITT3787
- Catalog: ITT3787
- Gene/Protein: PLN
- Product Description: Immunotag™ PLB Polyclonal Antibody
385.0000
Price in reward points: 385
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Antibody Specification | |
Datasheet | |
Target Protein | PLB |
Clonality | Polyclonal |
Storage/Stability | -20°C/1 year |
Application | IF,ELISA |
Recommended Dilution | Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications. |
Concentration | 1 mg/ml |
Reactive Species | Human,Mouse,Rat |
Host Species | Rabbit |
Immunogen | Synthesized peptide derived from PLB, at AA range: 1-80 |
Specificity | PLB Polyclonal Antibody detects endogenous levels of PLB protein. |
Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen |
Form | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Gene Name | PLN |
Accession No. | P26678 P61014 P61016 |
Alternate Names | PLN; PLB; Cardiac phospholamban; PLB |
Description | phospholamban(PLN) Homo sapiens The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016], |
Cell Pathway/ Category | Calcium,Dilated cardiomyopathy, |
Protein Expression | Liver,Testis, |
Subcellular Localization | mitochondrion,endoplasmic reticulum,membrane,integral component of membrane,mitochondrial membrane,vesicle,sarcoplasmic reticulum membrane,protein complex,perinuclear region of cytoplasm,calcium ion-transporting ATPase complex, |
Protein Function | disease:Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.,PTM:Phosphorylated in response to beta-adrenergic stimulation.,similarity:Belongs to the phospholamban family.,subunit:Homopentamer.,tissue specificity:Heart., |
Usage | For Research Use Only! Not for diagnostic or therapeutic procedures. |