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ITT3787

ITT3787
  • Catalog: ITT3787
  • Gene/Protein: PLN
  • Product Description: Immunotag™ PLB Polyclonal Antibody
385.0000
Price in reward points: 385

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Immunotag™ PLB Polyclonal Antibody
Antibody Specification
Datasheet
Target Protein PLB
Clonality Polyclonal
Storage/Stability -20°C/1 year
Application IF,ELISA
Recommended Dilution Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Concentration 1 mg/ml
Reactive Species Human,Mouse,Rat
Host Species Rabbit
Immunogen Synthesized peptide derived from PLB, at AA range: 1-80
Specificity PLB Polyclonal Antibody detects endogenous levels of PLB protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene Name PLN
Accession No. P26678 P61014 P61016
Alternate Names PLN; PLB; Cardiac phospholamban; PLB
Description phospholamban(PLN) Homo sapiens The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016],
Cell Pathway/ Category Calcium,Dilated cardiomyopathy,
Protein Expression Liver,Testis,
Subcellular Localization mitochondrion,endoplasmic reticulum,membrane,integral component of membrane,mitochondrial membrane,vesicle,sarcoplasmic reticulum membrane,protein complex,perinuclear region of cytoplasm,calcium ion-transporting ATPase complex,
Protein Function disease:Defects in PLN are the cause of cardiomyopathy dilated type 1P (CMD1P) [MIM:609909]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.,function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum.,PTM:Phosphorylated in response to beta-adrenergic stimulation.,similarity:Belongs to the phospholamban family.,subunit:Homopentamer.,tissue specificity:Heart.,
Usage For Research Use Only! Not for diagnostic or therapeutic procedures.
Material Safety Data Sheet
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